Abstract: Clinical Analysis of 3-Dimensional Conformal Radiotherapy for Esophageal Carcinoma withSupraclavicular Lymph Node MetastasisWenbin SHEN, Shuchai ZHU, JunWAN, Shuguang LI, Cuihong ZHANG, Jingwei SU, Juan LI, Zhikun LIU, Youmei LICorresponding author: Shuchai ZHU, E-mail: wbshen1979@sina.comDepartment of Radiation Oncology, The Fourth Hospital, Hebei Medical University, Shijiazhuang 050011, ChinaThis work was supported by the Scientific Research Foundation from Health Bureau of Hebei Province (No. 07113)Abstract Objective: To study the prognostic factors for patients with esophageal carcinoma with supraclavicular lymph nodemetastasis after 3-dimensional conformal radiotherapy ( 3D-CRT ) and to evaluate the validity of the clinical staging. Methods: A totalof 68 esophageal carcinoma patients with supraclavicular lymph node metastasis treated by 3D-CRT were reviewed and the possibleprognostic factors were analyzed. The relationship between supraclavicular lymph node metastasis of esophageal cancer and clinicalstaging was investigated. Results: After radiotherapy for primary cancer, 26 patients had tumor complete regression ( CR ), 33 patientshad partial regression ( PR ), 9 patients had no response ( NR ). After treatment for supraclavicular lymph node metastasis, 49 patientshad CR and 19 patients had PR. The 1-, 2- and 3-year survival rates were 51.4 %, 34.0 %, and 15.0 %, respectively. The median surviv-al time was 15 months. Univariate analysis showed that the lesion location, the length of tumor, the radiation dose for the primary can-cer, celiac lymph node metastasis, the size of supraclavicular lymph node and chemotherapy were prognositic factors. Multivariate anal-ysis showed that the lesion location, the radiation dose for the primarily cancer, the size of supraclavicular lymph node and chemothera-py were independent prognostic factors. Patients with inferior esophageal carcinoma had lower survival rate and shorter median surviv-al time. Conclusion: Radiotherapy combined with chemotherapy is the major treatment for advanced esophageal carcinoma. For superi-or esophageal carcinoma, the supraclavicular lymph node metastasis is regional lymph node metastasis.Keywords Esophageal neoplasm; Radiotherapy; Neoplasm staging; Prognosis; Evaluation study